TIM3 InhibitorChemicals ResearchUpdated on Mar 25, 2019 View more like this | Visit SHIRLEY, NY | Contact BOCSCI INC |
TIM3
cell immunoglobulin and mucin domain 3 (TIM3) is a member of Tim family, which consists of 301 amino acids. The common structure of TIM3 molecules includes: variable region of N-terminal immunoglobulin, mucin domain, transmembrane region and intracellular region. At the same time, TIM3, as an immunological checkpoint, plays an important role in the immunomodulation of tumor microenvironment.
Molecular biological characteristics of TIM3
TIM3 and cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death factor-1 (PD-1) and their ligands (PD-L) all belong to immunological checkpoint molecules, and They activate co-stimulatory signals during the cytotoxicity of the cellular immune system to tumor cells. TIM3 was selectively expressed in T helper cells (Th1 and Th17),T regulatory cells (Treg), dendritic cells (DCs) and monocytes. TIM3 can reduce inflammation by inhibiting macrophage polarization to M1 in autoimmune diseases. Symptomatic reaction and lymphocytic infiltration. It inhibits the activation of Th1 cells in phagocytes.
cell immunoglobulin and mucin domain 3 (TIM3) is a member of Tim family, which consists of 301 amino acids. The common structure of TIM3 molecules includes: variable region of N-terminal immunoglobulin, mucin domain, transmembrane region and intracellular region. At the same time, TIM3, as an immunological checkpoint, plays an important role in the immunomodulation of tumor microenvironment.
Molecular biological characteristics of TIM3
TIM3 and cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death factor-1 (PD-1) and their ligands (PD-L) all belong to immunological checkpoint molecules, and They activate co-stimulatory signals during the cytotoxicity of the cellular immune system to tumor cells. TIM3 was selectively expressed in T helper cells (Th1 and Th17),T regulatory cells (Treg), dendritic cells (DCs) and monocytes. TIM3 can reduce inflammation by inhibiting macrophage polarization to M1 in autoimmune diseases. Symptomatic reaction and lymphocytic infiltration. It inhibits the activation of Th1 cells in phagocytes.
