Thromboxane A2 InhibitorChemicals ResearchUpdated on Aug 28, 2019 View more like this | Visit SHIRLEY, NY | Contact BOCSCI INC |
An Overview of Thromboxane A2
Thromboxane A2 is a prostaglandin derivative synthesized by thromboxane synthase after metabolism of arachidonic acid by cyclooxygenase, and is produced mainly by activated platelet stimulation in vivo. Thromboxane A2 is a major metabolite of arachidonic acid. Specifically, arachidonic acid is mainly found in cell membrane phospholipids. Under the action of lipoxygenase and cyclooxygenase, leukotriene and prostaglandin intermediate metabolite are produced. A variety of prostaglandin synthetases catalyze the production of thromboxane A2. Thromboboxane synthetase in platelets and macrophages catalyzes the conversion of intermediate metabolites of prostaglandins to thromboxane A2. Thromboxane A2 exerts biological effects in various tissues and cells by binding to seven transmembrane-coupled receptors (thromboxane A2 receptor, TP), and shows functions of promoting platelet aggregation, contraction of blood vessels, and mediating immune responses.
Thromboxane A2 is a prostaglandin derivative synthesized by thromboxane synthase after metabolism of arachidonic acid by cyclooxygenase, and is produced mainly by activated platelet stimulation in vivo. Thromboxane A2 is a major metabolite of arachidonic acid. Specifically, arachidonic acid is mainly found in cell membrane phospholipids. Under the action of lipoxygenase and cyclooxygenase, leukotriene and prostaglandin intermediate metabolite are produced. A variety of prostaglandin synthetases catalyze the production of thromboxane A2. Thromboboxane synthetase in platelets and macrophages catalyzes the conversion of intermediate metabolites of prostaglandins to thromboxane A2. Thromboxane A2 exerts biological effects in various tissues and cells by binding to seven transmembrane-coupled receptors (thromboxane A2 receptor, TP), and shows functions of promoting platelet aggregation, contraction of blood vessels, and mediating immune responses.
