T cell proliferation

Creative Biolabs provides SIAT® ex vivo DC-T cell proliferation assay service to assess the immunogenicity of biotherapeutic drug candidates using cells from HLA-typed donors. The SIAT® DC-T cell proliferation assay allows the use of whole proteins, and more importantly, it can assess the factors other than protein sequence that contribute to immunogenicity. High-resolution HLA II-typed donor blood samples are used to mimic the allele frequencies found in the global population or to provide representative coverage of a particular population of interest without the need of animal models. Information provided by this assay is very useful during the early development of biotherapeutic drugs in terms of lead selection, humanization, and/or de-immunization.