t cell antibody production

The hypervariable regions (also known as complementarity determining regions or CDRs) are thought to be the primary immunogenic sites within the variable region, but any part of the variable region of immunoglobulin may contribute to the structure of an idiotype. In a number of systems, the CDR3 region has been shown to be the highest contributor; however, contributions by CDR1 and CDR2 are not uncommon.