sumoylation

SUMO modification (Small Ubiquitin-like Modifiers) is a kind of post-translational modification of protein. It has a variety of modification and processing forms, and there are many types. SUMO modification mainly plays an important role in the assembly of nuclear proteins, maintaining genome integrity, and regulating intracellular signaling pathways. Mature protein drugs undergo a series of post-translational modifications and have specific biological activities. Naturally modified protein drugs need to determine the type of modification, identify the site of modification, and analyze the structure of the modification. And its specificity, accuracy and stability were measured. Therefore, according to the SUMO ubiquitination modification of the protein or polypeptide under test, the biological characteristics of the protein drug or polypeptide chain can be obtained, so as to reveal the SUMO ubiquitination modification sites and structures of the protein or polypeptide.