STAT1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,;STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that;translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various;ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a;variety of genes, which is thought to be important for cell viability in response to different cell stimuli and;pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.