Stapled Peptide DesignPharmaceutical InformationUpdated on Jul 30, 2019 View more like this | Visit SHIRLEY, NY | Contact Cathy Miller |
Creative Peptides provides multiple methods for synthesizing stapled peptides. below is a list of our available strategies (include but not limited to the following):
• Grubbs catalysts are routinely used in olefin metathesis to incorporate hydrocarbon staples into peptides.
• The high efficiency and mild conditions of “click” reaction (Copper-catalyzed Huisgen 1,3-dipolar cycloaddition reaction) combined with the ease of synthesis of the necessary unnatural amino acids, allows for facile synthesis of triazole-stapled peptides.
• UV-induced reaction between tetrazoles and alkenes has been used by Madden et al. to staple peptides for inhibition of the p53-MDM2/MDMX interaction.
• Grubbs catalysts are routinely used in olefin metathesis to incorporate hydrocarbon staples into peptides.
• The high efficiency and mild conditions of “click” reaction (Copper-catalyzed Huisgen 1,3-dipolar cycloaddition reaction) combined with the ease of synthesis of the necessary unnatural amino acids, allows for facile synthesis of triazole-stapled peptides.
• UV-induced reaction between tetrazoles and alkenes has been used by Madden et al. to staple peptides for inhibition of the p53-MDM2/MDMX interaction.
