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SRPK Inhibitor

Pharmaceutical Information

Updated on Jun 10, 2019

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An overview of SRPK

Serine-arginine protein kinase (SRPK) is an important component of the serine-threonine protein kinase family found in recent years and plays an important role in the process of serine-specific phosphorylation. The SRPK family has the function of phosphorylating RNA splicing that contains RS-structured domains. Also, SRPKs play an important role in the selective splicing of Messenger RNA (mRNA), chromatin redistribution of somatic cells and sperm, cell cycle and p53 regulation, and cell metabolic signaling.

Major types of SRPK

There are many SRPKs have been found, such as SRPK1. SRPK1 is an RNA splicing kinase with high specificity for serine/arginine rich domain (RS domain). And SRPK1 can identify arginine and phosphorylate the serine in the development of tumors, leading to the progression of tumors.
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