Sigma Receptor Inhibitor

Sigma receptor is a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are subdivided into two subtypes, sigma-1 and sigma-2. The sigma-1 receptor (σ1R) is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. The sigma-2 receptor (σ2R) has been found highly expressed in malignant cancer cells, and is currently under investigation for its potential diagnostic and therapeutic uses.