γ Secretase InhibitorsPharmaceutical InformationUpdated on Mar 25, 2019 View more like this | Visit SHIRLEY, NY | Contact Cathy Miller |
Mechanism of action
The researchers further explored the effects of different structures of beta and γ-secretase inhibitors on angiogenesis and tumor growth. Both gamma and beta-secretase inhibitors tested reduced endothelial cell proliferation without inducing cytotoxicity, inhibited the formation of capillary structures in vitro, and inhibited the sprouting of microvascular growth in the rat aortic ring model of angiogenesis. Furthermore, they effectively inhibit the growth and angiogenesis of human glioblastoma and human lung adenocarcinoma tumors xenografted into nude mice.
The researchers further explored the effects of different structures of beta and γ-secretase inhibitors on angiogenesis and tumor growth. Both gamma and beta-secretase inhibitors tested reduced endothelial cell proliferation without inducing cytotoxicity, inhibited the formation of capillary structures in vitro, and inhibited the sprouting of microvascular growth in the rat aortic ring model of angiogenesis. Furthermore, they effectively inhibit the growth and angiogenesis of human glioblastoma and human lung adenocarcinoma tumors xenografted into nude mice.
