screening antibodiesAgricultural BiotechnologyUpdated on Jul 8, 2018 View more like this | Visit SHIRLEY, NY | Contact Creative Biolabs |
Creative Biolabs now offers high-throughput screening service of internalizing antibodies to our customers around the world. Integrated with multiple leading-edge technology platforms, we can guarantee our clients with the most efficient and reliable service to isolate antibody candidates with internalization potential against various membrane targets.
Receptor-mediated internalization is a critical characteristic of therapeutic antibodies. Upon binding membrane target, the antibody-receptor complex can initiatively translocate into the cytosol via endocytosis, resulting in either degradation or recycling (mostly FcRn-mediated). Fc-mediated antibody internalization is closely related to the antibody in vivo half-life; more importantly, Fv-mediated antibody internalization, as in most cases, can cause target receptor down-regulation on the cell membrane, thus eliciting diverse downstream therapeutic effects. Many of the most famous antibody drugs on the market have internalization potentials as one important mechanism of action.
Receptor-mediated internalization is a critical characteristic of therapeutic antibodies. Upon binding membrane target, the antibody-receptor complex can initiatively translocate into the cytosol via endocytosis, resulting in either degradation or recycling (mostly FcRn-mediated). Fc-mediated antibody internalization is closely related to the antibody in vivo half-life; more importantly, Fv-mediated antibody internalization, as in most cases, can cause target receptor down-regulation on the cell membrane, thus eliciting diverse downstream therapeutic effects. Many of the most famous antibody drugs on the market have internalization potentials as one important mechanism of action.
