retroviral vector

Retroviral (simple retrovirus, γ-retrovirus, MLV) transfection is one of the mainstays of current gene therapy approaches, which contains a reverse transcriptase to enable the integration of artificial genes into the host genome in a stable status. Particularly, the retroviral vector can either be replication-competent or replication-defective, and the latter is the most common choice for research since the viruses are competent for additional rounds of virion replication and packaging with other genes.