Peptide C-Terminal ModificationPharmaceutical InformationUpdated on Dec 11, 2018 View more like this | Visit SHIRLEY, NY | Contact Cathy Miller |
The development and importance of C-terminal modification of peptides
Peptide-C-Terminal-Modification.pngThe posttranslational modification of eukaryotic proteins by the addition of isoprenyl lipids at their C-termimi was first observed in the 1970s and 1980s. Since then, more than a hundred proteins have been shown to be modified by C15 farnesyl or C20 geranylgeranyl groups, including most members of the Ras, Rho, and Rab familied of G proteins. The C-terminal of the peptide is synthesized as an amide to neutralize negative charge created by the C-terminal COOH. This modification is added to prevent enzyme degradation, to mimic native proteins, and in some cases to remove hydrogen bonding at the C-terminal of the peptides which may interfere with the assays.
Available C-Terminal Modification Services
Creative Peptides provides multiple peptides of C-terminal modification to meet your custom peptide need. These peptide modifications can be used to create synthetic peptide with the exact conformation of characteristics needed for specific applications.
Peptide-C-Terminal-Modification.pngThe posttranslational modification of eukaryotic proteins by the addition of isoprenyl lipids at their C-termimi was first observed in the 1970s and 1980s. Since then, more than a hundred proteins have been shown to be modified by C15 farnesyl or C20 geranylgeranyl groups, including most members of the Ras, Rho, and Rab familied of G proteins. The C-terminal of the peptide is synthesized as an amide to neutralize negative charge created by the C-terminal COOH. This modification is added to prevent enzyme degradation, to mimic native proteins, and in some cases to remove hydrogen bonding at the C-terminal of the peptides which may interfere with the assays.
Available C-Terminal Modification Services
Creative Peptides provides multiple peptides of C-terminal modification to meet your custom peptide need. These peptide modifications can be used to create synthetic peptide with the exact conformation of characteristics needed for specific applications.
