NF-kB

Nuclear factor kappa B (NFkB) is a rapid acting primary transcription factor that regulates the transcription of specific pro-inflammatory genes. Although it is found in nearly all animal cells types, it was first discovered interacting with a DNA sequence important for producing light chains in B cells. Therefore, it plays a key role in regulating immune response to infections. Irregularities of NFkB signaling have been associated with cancer, inflammation, and improper immune development.