muscle targeting

Innovative scientists of Creative Biolabs have developed a novel in vivo phage display platform for selecting tissue-specific peptides. Using this method, a great deal of peptides or protein ligands candidates, which is specific for the target muscle tissues, can be isolated form cell surface. Those selected peptides will contain fully in vivo characteristics and can be used for transporting therapeutic agents to muscles and improve drug specificity and efficacy. In addition, it is also possible to identify some novel muscle cell-surface receptors by this method and then provides important tools for improving the efficiency of gene transfer in mammalian muscles, such as developing targeted adenoviral vectors.