mhc peptide tetramerPharmaceutical ResearchUpdated on Apr 13, 2018 View more like this | Visit SHIRLEY, NY | Contact Cathy Miller |
Creative Peptides has launched a series of MHC-peptide Tetramer which are ready-to-use reagents conjugated to a fluorochrome group such as Brilliant Violet 421(BV421), phycoerythrin (PE), or allophycocyanin (APC).
In 1996, the development of reagents consisting of soluble MHC class I–peptide complexes, which was applied to detect CD8+ cells by flow cytometry, has effectively promoted a revolution of antigen-specific T cells. Traditionally, TCR (T cell receptor) has a low avidity and fast off-rate for MHC-peptides complexes, recombinant soluble monomeric MHC-peptide complexes have not been used to detect antigen-specific T cells. Recently, Stanford University School of Medicine has presented MHC-peptides tetrameric complexes (MHC tetramers) in the detection of antigen-specific T cells, thus provided an efficient method to visualize, quantify, phenotype and sort antigen-specific cytotoxic T lymphocytes (CTLs) directly from a wide range of biological samples and have now become standard reagents in laboratories around the world.
In 1996, the development of reagents consisting of soluble MHC class I–peptide complexes, which was applied to detect CD8+ cells by flow cytometry, has effectively promoted a revolution of antigen-specific T cells. Traditionally, TCR (T cell receptor) has a low avidity and fast off-rate for MHC-peptides complexes, recombinant soluble monomeric MHC-peptide complexes have not been used to detect antigen-specific T cells. Recently, Stanford University School of Medicine has presented MHC-peptides tetrameric complexes (MHC tetramers) in the detection of antigen-specific T cells, thus provided an efficient method to visualize, quantify, phenotype and sort antigen-specific cytotoxic T lymphocytes (CTLs) directly from a wide range of biological samples and have now become standard reagents in laboratories around the world.
