Membrane Protein Modeling

Profacgen adapts conventional homology modeling methods with several membrane-protein-specific steps to achieve better modeling results by avoiding any bias towards soluble globular proteins in the algorithm. In cases where structural information from closely related proteins is unavailable, distant structural homologues are exploited for the reconstruction of the core and loop regions. Over the years, we have accumulated extensive experiences with the modeling of various types of membrane proteins, including G protein-coupled receptors (GPCRs) and transport proteins. The resultant structural models are all quality verified and can be used for computational drug design, molecular dynamics simulation, as well as directing further experimental work such as structure-based protein engineering.