Linkers and SpacersPharmaceutical InformationUpdated on Aug 28, 2019 View more like this | Visit SHIRLEY, NY | Contact Cathy Miller |
Linkers, we can also call spacers, which can be used to link two molecules of interest to us. They are always flexible or stretched molecule. Depending on the field of design and application, we can construct plugins in peptides and different molecules to construct molecular structures that can be used for research. Generally, we can insert a linker between the peptide and the following molecules:
Peptide and biotin
Peptide and carrier proteins (KLH, BSA, etc.)
Peptide and fluorescent dyes
Peptide and tags
Different lengths of linkers can bind to any site on the peptide, usually via an amide bond. One common hydrophobic spacer is aminocaproic acid (Ahx), a common hydrophilic spacer is polyethylene glycol (PEG), and there are many other options. In recent years, PEGylation has been widely used method for improving the stability and bioavailability of peptides in vivo. If you need, please visit Peptide PEGylation.
Peptide and biotin
Peptide and carrier proteins (KLH, BSA, etc.)
Peptide and fluorescent dyes
Peptide and tags
Different lengths of linkers can bind to any site on the peptide, usually via an amide bond. One common hydrophobic spacer is aminocaproic acid (Ahx), a common hydrophilic spacer is polyethylene glycol (PEG), and there are many other options. In recent years, PEGylation has been widely used method for improving the stability and bioavailability of peptides in vivo. If you need, please visit Peptide PEGylation.
