IDO inhibitorChemicals ResearchUpdated on Jul 21, 2018 View more like this | Visit SHIRLEY, NY | Contact BOCSCI INC |
IDO, also referred to indoleamine 2,3-dioxygenase, is an enzyme that plays a role in suppressing the immune system through catalyzing the oxidative cleavage of Tryptophan because T cells undergoing antigen-dependent activation require tryptophan for cell proliferation and survival. IDO inhibitors may help to promote an enhanced immune response against the tumor by blocking the IDO enzyme which reduces the depletion of tryptophan.
Recent studies have been aimed at discovering why IDO becomes deregulated in cancer cells. Several experiments point to the gene BIN1 as potentially playing a key role in immunosuppression. BIN1 is a cancer suppressive gene that appears to limit cancer largely by limiting immune escape. Studies showed that deleting the BIN1 gene from cells resulted in superactivated IDO expression, which suppressed the activation of T cells in the local tumor environment. Frequent loss or attenuation of BIN1 has been found to accompany breast cancer, prostate cancer, melanoma, astrocytoma, neuroblastoma, and colon cancer.
Recent studies have been aimed at discovering why IDO becomes deregulated in cancer cells. Several experiments point to the gene BIN1 as potentially playing a key role in immunosuppression. BIN1 is a cancer suppressive gene that appears to limit cancer largely by limiting immune escape. Studies showed that deleting the BIN1 gene from cells resulted in superactivated IDO expression, which suppressed the activation of T cells in the local tumor environment. Frequent loss or attenuation of BIN1 has been found to accompany breast cancer, prostate cancer, melanoma, astrocytoma, neuroblastoma, and colon cancer.
