ICOS InhibitorPharmaceutical InformationUpdated on Mar 25, 2019 View more like this | Visit SHIRLEY, NY | Contact BOCSCI INC |
An Overview of ICOS
ICOS is a newly discovered costimulatory molecule. The costimulatory signal provided by ICOS on activated T cells can promote the proliferation of T cells, regulate the differentiation of T cells, and maintain the effect and function of activated T cells (including memory T cells). ICOS is a member of immunoglobulin superfamily, which is composed of 199 amino acids and is divided into three parts: extracellular Ig-V-like domain, transmembrane domain and cytoplasmic tail. ICOS, as a costimulatory molecule, is expressed only on activated T cells, promoting T cell differentiation and exerting effect. In addition, ICOS can protect memory T cells from apoptosis and promote T cell proliferation and cytokine secretion.
Major types of ICOS
The type of ICOS is the CTLA4/PD1/CD28 family, which is mainly expressed in activated Th2 cells. The ligands are human B7-H2 / ICOSL and mouse B7-associated protein 1 (B7RP-1) and up-regulate the expression of adhesion molecules and cytokines in activated Th2 cells. Meanwhile, they also promote B cells to differentiate into plasma cells and produce antibodies.
ICOS is a newly discovered costimulatory molecule. The costimulatory signal provided by ICOS on activated T cells can promote the proliferation of T cells, regulate the differentiation of T cells, and maintain the effect and function of activated T cells (including memory T cells). ICOS is a member of immunoglobulin superfamily, which is composed of 199 amino acids and is divided into three parts: extracellular Ig-V-like domain, transmembrane domain and cytoplasmic tail. ICOS, as a costimulatory molecule, is expressed only on activated T cells, promoting T cell differentiation and exerting effect. In addition, ICOS can protect memory T cells from apoptosis and promote T cell proliferation and cytokine secretion.
Major types of ICOS
The type of ICOS is the CTLA4/PD1/CD28 family, which is mainly expressed in activated Th2 cells. The ligands are human B7-H2 / ICOSL and mouse B7-associated protein 1 (B7RP-1) and up-regulate the expression of adhesion molecules and cytokines in activated Th2 cells. Meanwhile, they also promote B cells to differentiate into plasma cells and produce antibodies.
