Histone Acetyltransferases (HATs)

Histone acetyltransferases (HATs) are the workhorses of the epigenome. These enzymes have a huge role epigenetic regulation of gene expression. They catalyze the transfer of an acetyl group from acetyl-CoA to ε-amino group of a histone lysine residue. These acetylations then serve allow transcriptional access to DNA by either neutralizing the positive histone charge, or serving as a binding site for chromatin remolding complexes.