High Concentration Formulation (HCF) Technology

Creative BioMart proprietary formulation technology using the combination of amino acids is effective in stabilizing proteins by inhibiting the aggregation as well as reducing viscosity. In developing a high concentration formulation of protein, we start with evaluating the existing formulation at higher concentrations. Depending on the protein and concentration sought, a new, more stabilizing formulation may be needed. By screening a series of different salts and excipients, varying concentrations of each, we develop HCF. The protein’s stability is evaluated by multiple criteria, including aggregation, degradation, activity, concentration, and protein conformation.