her2 adc

Erb-b2 receptor tyrosine kinase 2(ERBB2), commonly referred to as HER2, is an epidermal growth factor (EGF) receptor family tyrosine kinase. It is also referred to as ERBB2, NEU, NGL, TKR1, CD340, MLN 19, or HER-2/neu under different circumstances and it is a unique EGF receptor. There is no reported ligand that interacts with HER2. It is not susceptible to any epidermal growth factor binding. However, HER2 forms heterodimers with other EGF receptors, especially HER1 and HER3, upon EGF binding to these receptors, and triggers downstream signaling cascades that promotes cell proliferation. More about her2 adc by Creative Biolabs