GPCR Screening

GPCRs are expressed throughout the body and modulate a wide array of essential physiological processes, including regulating the senses of vision, taste, and olfaction, as well as mediating cellular responses to hormones and neurotransmitters. GPCR signal transduction is accomplished by the binding of a receptor agonist to an exposed extracellular or intra-membrane site on the receptor, which induces a conformational change in the receptor protein. The assortment of known GPCR ligands is as expansive and diverse as the biological functions they regulate, including photons, ions, odorants, amino acids, peptides, nucleotides, lipids, and small organic molecules. Because of the range of biological processes and pathologies, the screening and profiling of GPCR is an important tool to select drug candidates in drug discovery industry.