glycosylation motif

Creative Biolabs has established a platform to predict a series of post-translational modifications of therapeutic proteins, such as antibodies, blood factors, hormones and interferons. Glycosylation is one of the common post-translational modifications. The carbohydrate attaches the amino acid residues at the nitrogen atom of Asparagine for N-Glycosylation and the oxygen atom of Serine and Threonine for O-linked glycosylation. When immunoglobulin V-genes contain Asparagine resides in the CDRs, an N-glycosylation motif may be formed during selection, of which approximately 20% antibodies are glycosylated in the variable regions.