fab antibodies

Compared with the full length antibodies, Fab fragments have some advantages. On one hand it is easy to penetrate tissues and can be generated by some simpler expression systems, such as E. coli. On the other hand, the Fab fragments lack Fc regions so that the interactions between Fc portions and Fc receptor will be removed. Therefore, the Fab fragments can enhance antibody specificity and reduce the effector functions. Fab fragment antibodies will become more and more important and popular.