Edrecolomab

Recombinant mouse monoclonal antibody expressed in Sp2/0 mouse myeloma cells binding to human EpCAM/17-1A. Edrecolomab is a mouse-derived monoclonal antibody targeting the cell-surface glycoprotein EpCAM/17-1A, which is expressed on epithelial tissues and on various carcinomas. Preliminary studies had shown promise of a possible use in patients with stage III colorectal carcinoma. However, when put to a phase III study it did not provide any benefit when compared to conventional chemotherapeutic agents. Edrecolomab was well tolerated in these studies and as such research has now concentrated on whether it can be of any use in other forms of cancer.