De novo Peptide Design

De novo design is an attractive approach for constructing designed peptides with predetermined structures and functions. Creative Peptides provides de novo design related services for peptides engineering, including peptides structure prediction, peptides folding and interactions, thermodynamics information, energetic state, stability, etc. De novo design requires deep understanding of the structure of a peptide and the correlated functions. It is accomplished either from scratch or by the modular approach.

The full de novo peptide design framework consists of three stages: an optimization-based sequence selection, fold specificity calculation, and approximate binding affinity calculation.