CXCR InhibitorPharmaceutical InformationUpdated on May 30, 2019 View more like this | Visit SHIRLEY, NY | Contact BOCSCI INC |
Major type of CXCR
CXCR includes seven CXC-type chemokine receptors, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, and CXCR7. CXCR1 gene is located on chromosome 2q35 and promotes the proliferation and metastasis of cancer cells. CXCR3 is a G protein-coupled chemokine receptor that is located on chromosome Xq13 and encodes 368 amino acids. CXCR3 is mainly expressed on the surface of activated T cells, which are also expressed in various malignant tumors, such as breast cancer, colon cancer and gastric cancer. CXCR4 gene is located on chromosome 2q21 and consists of 352 amino acids. High expression of CXCR4 is associated with tumor invasion and poor tumor prognosis. CXCR7 can be expressed on the surface of activated endothelial cells, lymphocytes, fetal liver cells and the like, while CXCR7 is overexpressed in gastric cancer. CXCR2 and CXCR6 play important roles in tumor invasion and metastasis. Down-regulation of CXCR2 expression reduced the expression of Ets-1, SRC-1, and JNK proteins and the phosphorylation of c-Jun and ERK1/2, thereby inhibiting the invasion and metastasis of tumor cells. Blocking CXCR6 expression can block Akt pathway and down-regulate MMP-9 (matrix metalloprotein-9) expression, and inhibit tumor cell metastasis and invasion.
CXCR includes seven CXC-type chemokine receptors, CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, and CXCR7. CXCR1 gene is located on chromosome 2q35 and promotes the proliferation and metastasis of cancer cells. CXCR3 is a G protein-coupled chemokine receptor that is located on chromosome Xq13 and encodes 368 amino acids. CXCR3 is mainly expressed on the surface of activated T cells, which are also expressed in various malignant tumors, such as breast cancer, colon cancer and gastric cancer. CXCR4 gene is located on chromosome 2q21 and consists of 352 amino acids. High expression of CXCR4 is associated with tumor invasion and poor tumor prognosis. CXCR7 can be expressed on the surface of activated endothelial cells, lymphocytes, fetal liver cells and the like, while CXCR7 is overexpressed in gastric cancer. CXCR2 and CXCR6 play important roles in tumor invasion and metastasis. Down-regulation of CXCR2 expression reduced the expression of Ets-1, SRC-1, and JNK proteins and the phosphorylation of c-Jun and ERK1/2, thereby inhibiting the invasion and metastasis of tumor cells. Blocking CXCR6 expression can block Akt pathway and down-regulate MMP-9 (matrix metalloprotein-9) expression, and inhibit tumor cell metastasis and invasion.
