Chelate PeptidesPharmaceutical InformationUpdated on Mar 25, 2019 View more like this | Visit SHIRLEY, NY | Contact Cathy Miller |
DOTA is an organic compound and commonly used as a complexing agent, which has been widely used as contrast agent for cancer treatments. It can also be linked to molecules that have affinity to various structures (e.g. somatostatin receptors on neuroendocrine tumours). The generated compounds may combine with a number of radioisotopes to be used in cancer therapy and diagnosis. Complexes of DOTA peptides, depending on the metal ion, have found applications in three major areas: magnetic resonance imaging [GdIII), Eu(III)], nuclear imaging [111In(III), 68Ga(III), 64/67Cu(II)], and therapeutic radiopharmaceuticals [90Y(III), 177Lu(III)].
For example, DOTA could act as a chelator for a radionuclide. (Tyr3)-octreotate, a derivative of octreotide, can bind to somatostatin receptors that are found on the cell surfaces of a number of neuroendocrine tumours. Therefore, DOTA-(Tyr3)-Octreotate is able to direct the radioactivity into the tumour.
For customized DOTA peptides please visit our Peptides-Metal Chelates Conjugation page.
For example, DOTA could act as a chelator for a radionuclide. (Tyr3)-octreotate, a derivative of octreotide, can bind to somatostatin receptors that are found on the cell surfaces of a number of neuroendocrine tumours. Therefore, DOTA-(Tyr3)-Octreotate is able to direct the radioactivity into the tumour.
For customized DOTA peptides please visit our Peptides-Metal Chelates Conjugation page.
