CD45RO antibody

The CD45 family consists of multiple members that are all products of a single complex gene. Three isoforms of CD45 exist: on B-lymphocytes, where the protein is called B220 (its molecular mass is 220 kDA); on naive T-lymphocytes, where it is called CD45 RA, and on activated and memory T-lymphocytes, where it is called CD45 RO. CD45RO is a single-chain, transmembraneous glycoprotein which represents the low molecular weight isoform of the Leukocyte Common Antigen (LCA). It is expressed on most thymocytes, about 45% of peripheral blood T-cells, virtually all T-cells in skin reactive infiltrates, and the majority of T-cell malignancies. It is also found on a subset of B-cells and on exceptional B-cell Lymphomas.