CD39 InhibitorPharmaceutical InformationUpdated on Mar 25, 2019 View more like this | Visit SHIRLEY, NY | Contact BOCSCI INC |
Agonist of CD39
The expression of CD39 is mainly driven by the specific transcription factor Foxp3, other factors include interleukin-6 (IL-6), transforming growth factor-β(TGF-β) and hypoxia induced factor 1 (hypoxia inducible factor-1 (HIF-1). In animal experiments, almost all CD39 is expressed on the surface of Foxp3+Treg, and about 60% of CD73 is expressed on the surface of Foxp3+Treg, so on most of the Foxp3+Treg surfaces, CD39 and CD73 are co expressed.
CD39 and Diseases
CD39 is closely related to the occurrence and development of tumor as studies with statistical significance revealed. The expression of CD39 in many malignant tumors has been found to be significantly higher than that in normal tissues, such as kidney, lung, ovary, pancreas, thyroid and so on. A large number of studies have confirmed that targeting CD39 can inhibit the proliferation of tumor cells, reverse the function of immune cells, and enhance the immune effect. In recent years, the use of CD39 chemical inhibitors, monoclonal antibodies in vivo and in vitro experimental anti-tumor treatment has achieved a significant effect, providing a new way for anti-tumor therapy.
Reference:
Li Huijuan, Ye Liang, et al. A. (2018). Research Progress of CD39 in tumor immunity. Military Medical Journal of Southeast China. 20(1);45-49
The expression of CD39 is mainly driven by the specific transcription factor Foxp3, other factors include interleukin-6 (IL-6), transforming growth factor-β(TGF-β) and hypoxia induced factor 1 (hypoxia inducible factor-1 (HIF-1). In animal experiments, almost all CD39 is expressed on the surface of Foxp3+Treg, and about 60% of CD73 is expressed on the surface of Foxp3+Treg, so on most of the Foxp3+Treg surfaces, CD39 and CD73 are co expressed.
CD39 and Diseases
CD39 is closely related to the occurrence and development of tumor as studies with statistical significance revealed. The expression of CD39 in many malignant tumors has been found to be significantly higher than that in normal tissues, such as kidney, lung, ovary, pancreas, thyroid and so on. A large number of studies have confirmed that targeting CD39 can inhibit the proliferation of tumor cells, reverse the function of immune cells, and enhance the immune effect. In recent years, the use of CD39 chemical inhibitors, monoclonal antibodies in vivo and in vitro experimental anti-tumor treatment has achieved a significant effect, providing a new way for anti-tumor therapy.
Reference:
Li Huijuan, Ye Liang, et al. A. (2018). Research Progress of CD39 in tumor immunity. Military Medical Journal of Southeast China. 20(1);45-49
