BTLA InhibitorChemicals ResearchUpdated on Mar 25, 2019 View more like this | Visit SHIRLEY, NY | Contact BOCSCI INC |
Inhibition of BTLA
It was found that the combination of high immunogenicity vaccine expressing E7 and HSV-1 glycoprotein d could block the signal transduction of BTLA-HVEM and result in strong immune activity of CD8 T cells. In addition, the combination of soluble BTLA (sBTLA) and heat shock protein 70 (HSP70) also inhibited the expression of BTLA and enhanced the immune response. sBTLA could compete with BTLA in HVEM. The HSP70 vaccine could enhance Th1 cell function and promote the secretion of cytokines IL-2 and IFN-γ.
It was found that the combination of high immunogenicity vaccine expressing E7 and HSV-1 glycoprotein d could block the signal transduction of BTLA-HVEM and result in strong immune activity of CD8 T cells. In addition, the combination of soluble BTLA (sBTLA) and heat shock protein 70 (HSP70) also inhibited the expression of BTLA and enhanced the immune response. sBTLA could compete with BTLA in HVEM. The HSP70 vaccine could enhance Th1 cell function and promote the secretion of cytokines IL-2 and IFN-γ.
