B7-H4 InhibitorChemicals ResearchUpdated on May 30, 2019 View more like this | Visit SHIRLEY, NY | Contact BOCSCI INC |
An Overview of B7-H4
An important negative regulator of the immunoglobulin B7 family is the B7-H4. B7-H4 protein consists of 282 amino acids. The extracellular amino acids share 20% ~ 30% homology with other members of B7. The main biological function of B7-H4 is the inhibition of immune response. The inhibition of T cell mediated immune response by B7-H4 is generally through three ways: one is to inhibit T cell proliferation, the other is to inhibit T cell activity, and the third is to inhibit cytokines such as IL-2 secretion. B7-H4 inhibited the secretion of IL-10 and IFN-γ, and inhibited the proliferation and activity of CD4+ T cells and CD8+ T cells. The specific antibody blocked B7-H4 and promoted T cell immune response. B7-H4 expression was also detected in the blood of tumor patients, and the soluble B7-H4 also inhibited T cell mediated immune response. Mice with B7-H4 deficiency could form normal CTL reaction in antiviral infection, and their antitumor immune reaction was stronger than that in normal mice.
An important negative regulator of the immunoglobulin B7 family is the B7-H4. B7-H4 protein consists of 282 amino acids. The extracellular amino acids share 20% ~ 30% homology with other members of B7. The main biological function of B7-H4 is the inhibition of immune response. The inhibition of T cell mediated immune response by B7-H4 is generally through three ways: one is to inhibit T cell proliferation, the other is to inhibit T cell activity, and the third is to inhibit cytokines such as IL-2 secretion. B7-H4 inhibited the secretion of IL-10 and IFN-γ, and inhibited the proliferation and activity of CD4+ T cells and CD8+ T cells. The specific antibody blocked B7-H4 and promoted T cell immune response. B7-H4 expression was also detected in the blood of tumor patients, and the soluble B7-H4 also inhibited T cell mediated immune response. Mice with B7-H4 deficiency could form normal CTL reaction in antiviral infection, and their antitumor immune reaction was stronger than that in normal mice.
