antibody humanization

Since the first hybridoma has been obtained, a kind of possibility has arisen to modify the antibody to enhance its functionality. During this decade, antibody has become a major class of new drugs to treat several disease indications including cancer and autoimmune diseases. As the foundation of many diagnostics and therapeutics, the specific antigen binding ability of antibodies is critical for variety purposes, such as expanding detection limits, extending dissociation half-life time, decreasing therapeutic dosages and increasing overall efficacy. Nevertheless, it is still beneficial to optimize these antibodies or antibody related molecules with respect to their activity.