AAV guide

Adeno-associated virus (AAV) is classed into the family of Parvoviridae and the genus Dependovirus. This classification is based on the fact that AAV depends on the coinfection of an unrelated helper virus (e.g. adenovirus, herpesvirus, papillomavirus, or human cytomegalovirus) for productive infection. So far, 14 serotypes and multiple variants have been described, which were isolated, either as contaminants of adenoviral preparations or from integrated proviral sequences found in rodents, nonhuman primates and human tissues.