building block synthesis

During the last decades, the synthesis of building blocks has been explored by numerous groups, which are used in pharmaceutical products and other biologically active substances. Building blocks are important intermediates for many drugs and have major significance in the discovery and synthesis of drugs. Many important substances and some significant effect of natural drugs and synthetic drugs, such as chlorophyll, heme, and nucleic acid, contain heterocyclic structure. The heterocyclic compounds or heterocyclic compounds containing nitrogen atoms or fluorine atoms can be introduced into building blocks. Further building blocks as intermediates can be used to synthesize the subsequent drugs or compounds, which can improve or change the properties of the drugs or compounds. In addition, the introduction of sulfur and nitrogen-containing sulfonamide on the molecules of isopimaric acid can wide the range of effective anti-cancer activity of isopimaric acid. In a word, some necessary group can be introduced into building blocks and change the properties of subsequent compounds.