Perkins is an unincorporated community in western Scott County, Missouri, United States. It is located sixteen miles northwest of Sikeston.
A post office called Perkins has been in operation since 1890. The community has the name of Amos Perkins, a businessperson in the local lumber industry.
Perkins is found in the St. Louis Southwestern Railway Northern Division Employee Time Table No. 10 dated August 18, 1935. Perkins was station I-24 at milepost 23.76. It had a 20 car siding. In 1935 terms that was 900 feet long, as the then standard car was 45 feet in length. There was a mail crane at Perkins. It was a flagstop for passenger trains #5 and #6. Nearby Randles had a day/night telegraph and long lap sidings to meet trains.