Programmed Death-1 and Programmed Death Ligand-1 Inhibitors Market Trends and Demand Forecast to 2025

The growth of the global market is largely driven by the increased investment and funding, strong pipeline, and improved safety and efficacy. BGB-A317, a Phase I therapeutic candidate of BeiGene Ltd., gained $75 million funding to continued development of targeted oncology candidate. PD-1 and PD-L1 inhibitors are applicable to a wider range of tumor types such as advanced or metastatic non-small cell lung cancer, renal cancer, melanoma and others. These inhibitors lower the rate of severe toxicities and immune-mediated side-effects. These are also convenient to administer, and yield a good response rate of any single-agent immunotherapy. This creates huge traction in pharmaceutical industry to develop PD-1 and PD-L1 inhibitors for treatment of different types of cancer.

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Some of the other factors driving the growth of the global market include technological advancements and innovations, and high prevalence of cancer. Less number of competitors and expected launch of Phase III drug candidates will create ample growth opportunities for the global market. However, high cost of research and therapy, and stringent and time consuming regulatory process are the key barriers for the growth of the global market.

PD-1 and PD-L1 inhibitors are highly growing immunotherapies that are being used in oncology therapy area. The pipeline of PD-1 and PD-L1 inhibitors is enriched with 47 drugs and there are approximately 245 active clinical studies. Currently, durvalumab from Astrazeneca and atezolizumab from Roche are among the most promising molecules in the pipeline, in terms of efficacy and safety.

These molecules are in Phase III stage and expected to be launched in the coming years for the treatment of non-small cell lung cancer. There are many drugs in early stage of pipeline; thus, making PD1 and PDL1 inhibitors market very lucrative.

Among the two mechanism of action, the PD-1 inhibitors were estimated to contribute 97.2% to the global PD-1 and PD-L1 inhibitors market in 2016. However, the approval of Tecentriq and expected approval of durvalumab and avelumab during forecast period will significantly increase PD-L1 inhibitors revenue contribution to the global market.

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Some of the key players operating in the global market include Merck & Co., Inc., Bristol-Myers Squibb Company, AstraZeneca plc, Pfizer Inc., F. Hoffmann-La Roche AG, Novartis AG, Regeneron Pharmaceuticals, Inc., Ono Pharmaceutical Co., Ltd., and Merck KGaA.

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