Myrtle is a small, unincorporated community in Oregon County, Missouri, United States. It lies southeast of Alton, east of Thayer and approximately north of the Arkansas state line. The community lies on a low ridge above the south side of Mill Creek along Missouri Route V.
Myrtle was laid out in 1878 by Jessie Moore, and named after his daughter Myrtle Moore. A post office called Myrtle has been in operation since 1884.
Children attend Couch Public School which lies approximately three miles northwest of town along Missouri Route 142.